Subash Sad, Ph.D.
Professor, Department of Biochemistry, Microbiology and Immunology
Director, Microbiology and Immunology Graduate Program
Director, Centre for Infection, Immunity and Inflammation
Subash Sad is a Cellular Immunologist. He has a background training in Mathematics, Biochemistry and Immunology, which has allowed him to use cross-disciplinary approaches to decipher the key mechanisms that lead to disease progression. During his Ph.D. (1987-1992), Subash Sad deciphered a vaccine approach to generate antibodies against the hormone, GnRH. This work revealed that induction of antibodies against GnRH results in shrinkage of prostate, which was then translated successfully to treat androgen-dependent prostate cancers. Subash Sad pursued his post-doctoral work with Dr. Tim Mosmann, at the University of Alberta, where he discovered that different cytokine-secreting subsets of T cells are derived from a common precursor cell. He also identified other cytokine secreting subsets of T cells in other T-cell lineages. In 1997, Subash Sad joined the National Research Council of Canada as a scientist, where he identified the mechanisms through which memory T cells are generated and maintained during acute and chronic infections. In 2012, Subash Sad joined the University of Ottawa, Faculty of Medicine, as a professor. He is the founding director of the Centre for Infection, Immunity and Inflammation (CI3), wherein he collaborates with fundamental and clinical scientists to find solutions to chronic diseases. Subash Sad has trained numerous graduate students and post-doctoral fellows in his laboratory. He is the director of the microbiology graduate program at the University of Ottawa, and also teaches Immunology to undergraduate and graduate students.
We are studying how excessive systemic inflammatory responses lead to septic shock and necrotic death of the host cells.
We are studying how the presence of opportunistic pathogens can aggregate the inflammatory pulmonary exacerbations experienced by cystic fibrosis patients.
Inflammatory Bowel Disease
We are studying how genetic mutations can influence the susceptibility and progression of inflammatory diseases.
National Institute of Immunology, New Delhi
University of Kashmir
University of Kashmir