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Cai D., Brickey W.J., Ting J.P., and Sad S. (2022). Isolates of Salmonella typhimurium circumvent NLRP3 in inflammasome recognition in macrophages during the chronic phase of infection. J. Biol. Chem. 298 (1); 101461. In press.

Hajjar S., Nathan N., Joseph J., Mottawea W., Ariana A., Pyatibrat S., Harper M-E., Alain T., Blais A., Russell R.C., and Sad S. (2022). Foxo3a tempers excessive glutaminolysis in activated T cells to prevent fatal gut inflammation in the murine IL-10−/− model of colitis. Cell Death & Differentiation. 29(3); 585-599.

Phuong MS, Hernandez RE, Wolter DJ, Hoffman LR, Sad S. Impairment in inflammasome signaling by the chronic Pseudomonas aeruginosa isolates from cystic fibrosis patients results in an increase in inflammatory response. Cell Death Dis. 2021 Mar 4;12(3):241. doi: 10.1038/s41419-021-03526-w. PMID: 33664232; PMCID: PMC7933143.

Sadh S, Hajjar S, Ariana A, Phuong MS, Cai D, Thakker P, Sad S. Coating M-CSF on plastic surface results in the generation of increased numbers of macrophages in vitro. J Immunol Methods. 2020 Jun-Jul;481-482:112788. doi: 10.1016/j.jim.2020.112788. Epub 2020 Apr 15. PMID: 32304707.

Ariana A, Alturki NA, Hajjar S, Stumpo DJ, Tiedje C, Alnemri ES, Gaestel M, Blackshear PJ, Sad S. Tristetraprolin regulates necroptosis during tonic Toll-like receptor 4 (TLR4) signaling in murine macrophages. J Biol Chem. 2020 Apr 3;295(14):4661-4672. doi: 10.1074/jbc.RA119.011633. Epub 2020 Feb 24. PMID: 32094226; PMCID: PMC7135981.

Shutinoski B, Patel R, Tomlinson JJ, Schlossmacher MG, Sad S. Ripk3 licenced protection against microbial infection in the absence of Caspase1-11 inflammasome. Microbes Infect. 2020 Jan-Feb;22(1):40-45. doi: 10.1016/j.micinf.2019.08.002. Epub 2019 Aug 17. PMID: 31430539.

Rijal D., Ariana A., Wight A., Kim K., Alturki N.A., Aamir Z., Ametepe E.S., Korneluk R.G., Tiedje C., Menon M.B. Gaestel M., McComb S. and Sad S. (2018). Differentiated macrophages acquire a pro-inflammatory cell death-resistance phenotype due to increased XIAP and P38-mediated inhibition of RipK1. J. Biol. Chem. 293(30):11913-11927.

Joseph J., Ametepe E.S., Haribabu N., Agbayani G., Krishnan LK., Blais A. and Sad S. (2016). Inhibition of ROS and upregulation of inflammatory cytokines by FoxO3a promotes survival against Salmonella typhimurium. Nature Commun. 7:12748.

McComb S., Cessford E., Alturki N.A., Joseph J., Shutinoski B., Startek J.B., Gamero A.M., Mossman K.L., Sad S. (2014). Type-I interferon signaling through ISGF3 complex is required for sustained Rip3 activation and necroptosis in macrophages. Proc. Natl. Acad. Sci. (USA). Aug 5; 111(31): E3206-13.

Robinson N., McComb S., Mulligan R., Dudani R., Krishnan L. and Sad S., (2012) Type I interferon induces necroptosis in macrophages during Salmonella Typhimurium infection. Nature Immunol., Oct;13(10):954-962.


“The joy of discovery is certainly the liveliest that the mind of man can ever feel”

- Claude Bernard -

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